I have a need to write about a drug that was first given to me by an elderly Russian cardiologist. She is now long retired, but she was the best doctor I have ever had. She was very old school and very good in her knowledge of heart issues. It is the information that she gave me and Svetochka years ago, that continues to be the catalyst for my continual improvement in my condition. There is two pills that will never leave my side as I grow older and older. The first is cardiac aspirin in the 80mg dosage. This thins my blood and will be my companion for life. The next drug is Kardiket…
Kardiket has given me my life back and allows me to live life free of many issues. It is a very powerful drug and misused it can be a killer. Fast killer!
I take it twice a day and it stabilizes me to the point that I am able to exercise, work and play with very little issues. I know that I will take this nitro long term pill for life and am thankful that it is dirt cheap in Russia. Just a few bucks for a months supply…
Sadly: Kardiket is very expensive in the west. I see prices approaching $100 a month for the amount I take every month and that is a very big issue in the western world and one of the many things I talk about on this blog. I take a life saving drug for pennies on the dollar, in comparison to what I would pay if I still lived in the states…
Here is Kardiket and the information of who, what and why…
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Name: Kardiket
Pharmachologic effect:
Kartiket has antianginal effects. It consists of isosorbide dinitrate (organic nitrate). Increase peripheral arteries and veins. This is accompanied by a deposit in the peripheral vascular blood network, thereby reducing venous return to the heart, reduced end-diastolic pressure, decreased volumetric filling of the left ventricle. For internal use is dissolved in a few minutes in the stomach. The release of active substance from the pellets is observed for a prolonged time. The effect is to quickly and lasts for a long time. Rapidly absorbed, it takes effect within 15 minutes. The maximum blood concentration is observed after 15 minutes (maintained for 1-2 hours). Bioavailability is 22%, blood proteins bind 30% of the drug. In hepatocytes transformed to isosorbide-2-mononitrate and isosorbide-5-mononitrate. The half-life of metabolites – 4-6 and 1.5-2 hours respectively. It eliminated by the kidneys as metabolites.
Indications for use:
• heart ischemic disease therapy for a long time, the prevention of angina attacks;
• prevention infarction (secondary) – used long-acting dosage forms kardiket;
• as part of a treatment for chronic heart failure (diuretics, cardiac glycosides, and angiotensin-converting factor).
Mode of application:
The therapy begins with the most minimal doses. increase the dose to the most effective should be carried out slowly. The duration of therapy is determined individually by your doctor. Designed exclusively for prolonged use, so you can not abruptly stop use kardiket without consulting a doctor.
Kardiket administered orally, washed down with a small amount of water, regardless of meals. Do not chew. When you need to separate in half a tablet is placed on a hard surface so that the fault line was on top and press down with your finger on the line.
Tablets prolonged by 20 mg administered on 1 piece, 2 times a day. If necessary, the dosage may be increased – 1 tablet 3 times daily.
Prolonged tablets 40 mg is first applied on one tablet / day (or half tablets 2 times a day). If necessary, increase the dose to one pill 2 times per day with an interval of at least 8 hours.
Tablets prolonged by 60 mg administered as initial therapy: 1 tablet / day. If necessary, increase to 2 tablets / day at intervals of at least 8 hours.
The long-acting capsules are used by 120 mg / day.
Side effects:
Cardiovascular system: nitrate headaches (at the beginning of therapy) – usually disappear after a few days of taking the drug; hypotension, palpitations, orthostatic collapse, lethargy, feeling of weakness, paradoxical bradycardia, loss of consciousness against the background of decrease in heart rate (syncope), paradoxical angina.
Central nervous system: drowsiness, blurred vision, stiffness, ischemic disorders, slowing the speed of the psycho-motor response.
Gastrointestinal: vomiting, nausea, dry mouth, epigastrium pain, belching.
Allergic reactions: urticaria.
Other: exfoliative dermatitis, the development of tolerance to kardiket or other nitrate drugs, redness of the skin.
Contraindications:
Absolute:
• acute myocardial infarction, which is accompanied by a significant decrease in blood pressure;
• shock, collapse and other forms of acute cardiovascular insufficiency;
• hypotension with figures in systolic blood pressure less than 90 mm Hg .;
• closure form of glaucoma with a significant increase in intraocular pressure;
• heart disease – Mitra and / or aortic stenosis;
• traumatic brain injury;
• hemorrhagic stroke;
• persons under 18 years (since the safety and efficacy for use in this age group have not been established);
• hypersensitivity to other nitrates;
• hypovolemia;
• combination with tadalafil, sildenafil, varnenafrilom (and other inhibitors of the enzyme 5-type diesterazy) – since These drugs increase blood pressure reduction of nitrates.
Relative:
• cardiomyopathy hypertrophic obstructive (risk of increased frequency of angina attacks);
• cardiac tamponade;
• severe anemia;
• pulmonary edema toxic origin;
• constrictive pericarditis;
• hemorrhagic stroke, bleeding in the brain.
Pregnancy:
Pregnant and lactating mothers kardiket appointed only if the anticipated positive effects for women prevail over potential risk to the fetus (child).
Interaction with other drugs:
When co-administered with other vasodilators, means to lower blood pressure, slow calcium channel blockers, antipsychotics, tricyclic antidepressants, ethanol, quinidine, blockers, inhibitors of the enzyme phosphodiesterase type 5, novokainamidom, drugs to treat impotence kardiket hypotension effect is potentiated.
In combination with dihydroergotamine hypotensive effect is enhanced by increasing the latter in its blood concentration. Reducing kardiket anti-anginal effect can occur when combined with sympathomimetics and alpha-blockers.
The most efficient in the treatment of coronary heart disease is a combination of co-administration kardiket with nifedipine, propranolol, amiodarone.
Simultaneous treatment with acetylsalicylic acid improves blood circulation in coronary vessels.
Increased intraocular pressure is possible with a combination kardiket with atropine or other M-holinoblokatorami. Kardiket absorption from the stomach is reduced enveloping and binding agents.
Overdose:
In case of overdose kardiket observed a strong decrease in blood pressure, loss of consciousness, collapse, dizziness, headache, redness of the skin, visual disturbances, nausea, vomiting, diarrhea, palpitations, cyanosis of the skin and mucous membranes and anoxia (due per methemoglobin), decrease in heart rate, paralysis coma; hyper, dyspnea; perspiration, brain hypotension. If symptoms of overdose must enter into a vein 1% solution of methylene blue at the rate of 1-2 mg / kg body weight (with methemoglobin). epinephrine Symptomatic therapy is ineffective.
Product form:
Sustained-release tablets 20 mg (white, circular shape, one side is flat, and the risk chamfer on one side engraved letters «IR» and the numeral “20” engraved on the other side.
On prolonged action tablets with 40 mg instead of the “20” engraved “40” for prolonged action tablets 60 instead of the “20” engraved “60”. Other characteristics of the tablets are the same.
Capsules 120 mg – gelatin, hard, light brown, capsules containing granules of white or white-yellow practically odorless or with a slight odor.
The long-acting tablets in stripes package packed in a cardboard package 20 or 50 tablets. Capsules – 10 pieces in blisters, carton box.
Storage conditions:
Keep out of the reach of children, dry and at a temperature not exceeding 25 ° C. Shelf life of kardiket – 5 years.
Composition:
The tablets of the prolonged action kardiket:
Active ingredient: isosorbide dinitrate.
Auxiliary ingredients: magnesium stearate, talc, potato starch,lactose onohydrate, polyvinyl acetate.
Capsules of prolonged action:
Active ingredient: isosorbide dinitrate.
Auxiliary components: sugar spheres, lactose, talc, poly-ethyl-0, shellat.
Active ingredient: isosorbide dinitrate
Additionally:
With tendency to hypotension, increased intracranial pressure, renal and or hepatic insufficiency, increased peristalsis of the gastrointestinal tract, hypothyroidism, malabsorption, the elderly should be used carefully under constant medical supervision.
Do not use for the relief of angina attacks. the appointment of the drug should be avoided in high doses – with the possible development of tolerance to both kardiket and other nitrates (cross tolerance).
When administered to patients with pulmonary diseases (primary) may develop transient hypoxemia as a result of redistribution of blood in less ventilated areas of the lung. If the patient has coronary heart disease – it can provoke myocardial ischemia transient in nature.
In acute cardiovascular disease and / or myocardial infarction in the acute phase must be careful medical observation of the patient, which takes kardiket.
Do not abruptly cancel the drug due to the risk of increased frequency of angina attacks.
If a patient develops angina while taking kardiket – must also enter the number of fast-acting nitrates. dose selection is carried out individually depending on the blood pressure. By paradoxical nitrate reaction reactions include lowering blood pressure, orthostatic hypotension, decreased blood pressure after ingestion of alcohol (ethanol), during exercise in hot weather. This may increase angina manifestations up to the development of myocardial infarction or sudden death.
In severe headache while taking kardiket must assign mentolsoderzhaschie drugs (validol) and or reduce the dose of kardiket.
At very frequent use may develop addiction, requiring an increase in dosage. To prevent such a state you must follow the mode of reception kardiket: needs daily medication-free interval (usually at night for 9-12 hours). This is more efficient than the constant intervals without kardiket therapy.
Treatment is canceled if the intake of kardiket there is a pronounced dry mouth and blurred vision, which are expressed strongly enough.
At the time of treatment kardiket absolutely can not drink alcohol and ethanol-containing preparations. During treatment is not recommended to drive vehicles engaged in the production of which requires intense concentration and focus speed photodisintegration reactions.
Attention!
Description “Kardiket” drug – Before purchasing or using the product, you should consult your doctor and see the summary approved by the manufacturer. Preparation of information being provided is for informational purposes and should not be used as a guide to self-healing. Only a doctor can decide on the appointment of the drug, and to determine the doses and methods of application.
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I know boring and dull! But hey it just may save your life and knowledge is the key to advancement and or a better existence…
As I said yesterday, Boza has now joined me in a daily medicine program and as we all get older, it seems that we must take pills and or drops in the eyes in Boza’s case, if it keeps us alive and doing better? We must do what we must…
Have a nice day and you just learned something new today…
WtR